Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.
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We wish you a successful ! Many cells and tissues contain very low endogenous levels of 5-fC that may fall below the detection limits of this antibody.
The same sequence of a base pair DNA fragment was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC. The modified base itself is stable in vivo and interacts with various readers including MeCP2 11, The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers. If so we’d love to hear about it. By proceeding on this website, you agree to the placement of these cookies.
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Contact us and we will help you. TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8. Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2. No need datassheet login to view prices! Application References Have you published research involving the use of our products?
Please select a country. The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue. The supporting documents available for this product can be downloaded below. Our website shows product prices without login! Therefore webshop accounts that were only used to view prices have been deleted. Please change your password to something memorable and secure upon logging in.
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Please refer to this page. Since then this modification has been discovered in many tissues, datashheet the highest levels found in the brain 9. Datasheet Datasheet CST The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC.
Login No need to login to view prices! Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 7178.
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Product has been added to your cart. Enter your username and we will send you a link to reset your password if an associated user is found. The current items in your cart are: You will receive an e-mail from us containing your new password in the coming minutes. Please let us know! Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper datashest of gene expression, genomic imprinting, and mammalian development 1,2.